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LHW090-A7 - CAS# 1308256-94-1 Catalog No.:M6427-10 G-749 shows strong inhibitory activity

LHW090-A7 - CAS# 1308256-94-1 Catalog No.:M6427-10 G-749 shows strong inhibitory activity

Name: LHW090-A7 - CAS# 1308256-94-1 Catalog No.:M6427-10 G-749 shows strong inhibitory activity
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LHW090-A7 - CAS# 1308256-94-1 Catalog No.:M6427-10 G-749 shows strong inhibitory activityLHW090 A7, CAS No. 1308256 94 1, is a compound developed as an inhibitor of neutral endopeptidase (NEP), an enzyme responsible for the metabolic inactivation of enkephalins. 1 Inhibitors of NEP have been shown to increase plasma levels of endogenous atrial natriuretic peptides and, as such, are expected to induce natriuretic and diuretic effects. Product information CAS Number: 1308256 94 1 Molecular Weight: 375. 85 Formula: C20H22ClNO4 Synonym:

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Description

G-749 shows strong inhibitory activity with IC50 of

Bollmann A

Spinelli L

is a potent inhibitor of ferroptosis with an EC50 ~60 nM

It acts most likely as a result of combined inhibition of DYRK1A and GSK3B

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