STX3 Rabbit Polyclonal Antibody, 100ul Protein Modification The protein (BCL2 like 11)

The protein (BCL2 like 11) encoded by BCL2L11 belongs to the BCL-2 protein family

The encoded protein| which acts as a tetramer by associating with another heavy chain and two light chains| interacts with protein kinase CK2

it is probably inactive as an hydrolase due to lack of the conserved zinc-binding and active sites

Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles

A frequent polymorphism in the translation start codon of this gene can abolish translation and may be associated with forms of deafness

STX3 Rabbit Polyclonal Antibody, 100ul Protein Modification The protein (BCL2 like 11)The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants.