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[1] Because its multiple ion-channel and neurotransmitter actions dampen pathologic cortical excitability, topiramate received United States marketing clearance in 1996 for monotherapy or adjunctive control of partial-onset and primary generalized tonic-clonic seizures

While the medication addresses multiple aspects of metabolic dysfunction, extremely insulin-resistant individuals may require higher doses or longer treatment duration to achieve comparable results

Semaglutide, for example, activates only the GLP-1 receptor

This technique uses a gentle, pulsatile water jet to mobilize and wash away the fatty tissue

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