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Although the atherosclerotic CV disease risk reduction and CKD progression benefits of SGLT-2 inhibitors may be found to be a class effect in future, the evidence for ertugliflozin (a third SGLT-2 inhibitor recently deleted from the market in Australia) is less robust with further studies ongoing

While the trial was primarily a non-inferiority study, a secondary analysis for superiority also showed a significant reduction in time to all-cause death [21]