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Hepatic effects that are considered adverse include death, abnormal clinical chemistry parameters, obvious functional organ impairment, DNA and mitochondrial alteration, glutathione depletion, hepatocyte necrosis, enhanced replicative DNA synthesis, generation of reactive oxygen species, and increased peroxisome proliferation (in rodents) (Williams and Iatropoulos 2002)

Contact your healthcare provider promptly if: Back pain persists beyond 23 weeks despite conservative measures Pain progressively worsens rather than improving Pain significantly interferes with daily activities or sleep Systemic symptoms develop (fever, night sweats) or unintentional weight loss beyond therapy goals Pain occurs in patients with cancer history or other risk factors for metastatic disease Flank pain accompanied by urinary symptoms (possible kidney stones or infection) Clinicians should obtain a thorough history, perform physical examination, and consider laboratory evaluation (including serum lipase and liver function tests) when indicated

pmid:20548286

Gallbladder problems: Warning signs include pain in your upper stomach area, fever, yellowing of your skin or the whites of your eyes, or clay-colored stools

Chem Res Toxicol 17(2):234242