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In nervous system

Alternatively spliced transcript variants have been found in this gene

and as a sorting receptor that binds to regulated secretory pathway proteins

HM74B lacks the characteristic N-linked glycosylation sites that are present in other GPCR family members and also shows a more diverged amino acid sequence homology from most family members

S10AE Polyclonal Antibody, 50ul Reagent Reservoirs Take action now and elevateThis gene encodes a member of the S100 protein family which contains an EF hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828).