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In this study, the authors used optogenetics to dissect the role of FOSB in a select population of neurons in limbic brain regions that send synaptic inputs to the NAc

Cell 149(5):1060

An animal study also shows that knockout specifically of SIRT1 in myeloid cells alleviates synovial inflammation and bone destruction of RA by decreasing Th1 and Th17 differentiation (304)

"Even people that are pretty healthy, boy, they're thinking about [GLP-1s] because my patients are rational and they understand this is evidence-based, and it does seem to have some longevity benefit." He doesn't broadly recommend the entire class of compounds, though