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Continue using appropriate splinting, especially at night when unconscious wrist positioning can aggravate symptoms

Figure 5 shows a statistically significant increase in ferritin levels in Group A (patients with COVID-19 = 467.11 ng/mL) as compared with Group B (healthy individuals = 62.2 ng/mL)

Therefore, while existing evidence supports low local toxicity, comprehensive in vitro and in vivo immunogenicity testing remains advisable prior to clinical translation [71, 191]