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Inflammation M2 macrophages in the rheumatoid arthritis (RA) synovial microenvironment are particularly susceptible to ferroptosis, where the HMGB1/ Toll-like Receptor 4 (TLR4)/STAT3 axis plays a pivotal role in exacerbating synovial inflammation [74]

In one study, participants who consumed a spermidine-rich diet for 3 months exhibited improved insulin sensitivity and lower fasting glucose levels, suggesting spermidines potential as a therapeutic agent for managing metabolic disorders (Reference Wirth, Benson and Schwarz99)

J Asian Nat Prod Res 24(3):278289

A fundamental biochemical principle is that SAH inhibits the majority of methyltransferases with low-micromolar inhibition constants (Ki)

Oxidative stress can be induced in two main ways: directly increasing ROS levels or impairing antioxidant defense systems