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This review first summarizes the metabolic reprogramming that occurs within the TME, including alterations in glucose, lipid, and amino acid metabolism in tumor cells, as well as the metabolic adaptation of immune cells

At the level of thyroid hormone synthesis, TNF- can directly inhibit the activity of thyroid peroxidase (TPO), and IL-1 stimulates iodothyronine 5-deiodine activity in the liver to affect the metabolism of thyroid hormone (Fujii et al., 1989)

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However, more research is needed to form a consensus on appropriate forms and dosing to address stress and stress-related disorders

eLife , 5 , e10727 Hu, W., Zhang, C., Wu, R., Sun, Y., Levine, A., & Feng, Z