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Side effects may recur or intensify with each dose escalation, even if initial symptoms had resolved at a lower dose

Lingvay I, Mosenzon O, Brown K, Cui X, ONeill C, Fernndez Land L, Patel H

Semaglutide may impair B12 absorption through its effects on gastric acid production and delayed gastric emptying

A benchmark, expand, and calibration (BenchExCal) trial emulation approach for using real-world evidence to support indication expansions: design and process for a planned empirical evaluation