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Neoptolemos JP, Davidson BR, Winder AF, Vallance D (1988) Role of duodenal bile crystal analysis in the investigation of idiopathic pancreatitis

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These multidirectional channels, which include microbial metabolites, immune cell movement, extracellular vesicles, and neuronal signals, work together to form an integrated gut-immune-brain network [109]

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They have been found in almost all branches of the tree of life, ranging from microorganisms over plants to mammalians