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186 Subsequently, it was shown that hamster and human preproglucagon cDNAs encode GLP-1 and 2, but only GLP-1 displayed incretin activity

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Evidence from the SURPASS phase III clinical trial program has consistently demonstrated the superior metabolic efficacy of tirzepatide compared with currently available GLP-1 receptor agonists, such as semaglutide

Abnormalities in glucose, electrolytes, or other CMP markers may suggest GLP-1 issues [25]

This finding was significant enough that the tirzepatide drug label now advises patients using oral hormonal contraceptives to switch to or add a non-oral contraceptive method when initiating tirzepatide and after each dose escalation