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While findings remain varied, DSIP continues to be of interest for its role in neuroendocrine regulation

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3 The levels of monoamine neurotransmitters (5-HT, NE, and DA) are insufficient in the synaptic cleft of MDD patients, correspondingly, the explored antidepressants such as tricyclic antidepressants(TCAs), SSRIs and SNRIs almostly act on the channels responsible for inhibiting reuptake of these neurotransmitters

Patients who do not return to the same health system after stopping their medication are not captured, potentially skewing weight outcomes toward those who remain more engaged with care

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