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Its four-residue sequence alanine, glutamic acid, aspartic acid, and glycine gives it two acidic side chains, making the molecule negatively charged at physiological pH

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Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]