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The discussion of oligomerization (page 3-8) is described elsewhere in detail (including cited references) and can be somewhat summarize here

El motivo del pH cido es fisicoqumico: Long R3 IGF-1 muestra mayor solubilidad y estabilidad en medio ligeramente cido, donde su plegamiento y sus puentes disulfuro se preservan mejor que en soluciones neutras o alcalinas, que favorecen la agregacin y la prdida de actividad