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Primary antibodies were applied and incubated overnight at 4C in Tris-buffered saline with Tween 20 (TBST)

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Human G1 and G2 were inserted into a pFastDual plasmid and were prepared by insertion of His 6 -tagged human G 1 fragment (BamHI/HindIII site) under the polh promoter and insertion of G 2 fragment (XhoI/SphI site) under the p10 promoter, respectively (Genewiz)